Synthesis and In Vitro Evaluation of Imidazo[1,2-b]pyridazines as Ligands for β-Amyloid Plaques was written by Zeng, Fanxing;Alagille, David;Tamagnan, Gilles D.;Ciliax, Brian J.;Levey, Allan I.;Goodman, Mark M.. And the article was included in ACS Medicinal Chemistry Letters in 2010.COA of Formula: C4H2F2N2 This article mentions the following:
A series of imidazo[1,2-b]pyridazine derivatives were synthesized and evaluated for binding to amyloid plaques in vitro using synthetic aggregates of Aβ1-40. Binding affinities of these compounds were found to range from 11.0 to >1000 nM, depending on the various substitution patterns in the 6-position and 2-position. 2-(4′-Dimethylaminophenyl)-6-(methylthio)imidazo[1,2-b]pyridazine (4) showed high binding affinity (Ki = 11.0 nM) and might be useful for the development of novel positron emission tomog. radiotracers for imaging Aβ plaques. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1COA of Formula: C4H2F2N2).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. In the past decade, X-ray data were reported with regard to the characterization and structural elucidation of a number of pyridazine-metal complexes, including pyridazine ligands with zinc, nickel, copper, cadmium and ruthenium.COA of Formula: C4H2F2N2
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem