Synthesis and herbicidal activity of 3-aryloxy-6-substituted pyridazines was written by Yang, Hua-Zheng;Wang, Xiang;Hu, Fang-Zhong;Yang, Xiu-Feng. And the article was included in Gaodeng Xuexiao Huaxue Xuebao in 2002.Safety of 3,6-Difluoropyridazine This article mentions the following:
A series of 3-aryloxy-6-substituted pyridazines have been synthesized and their herbicidal activity have been studied. All of above pyridazines have been confirmed by 1H NMR and elemental analyses, and some of them have been characterized by IR and MS. The bioassay result indicated that some of the title compounds have a high herbicidal activity. In addition, the structure-activity relationship was discussed. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Safety of 3,6-Difluoropyridazine).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Safety of 3,6-Difluoropyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem