Room-temperature nucleophilic aromatic fluorination: experimental and theoretical studies was written by Sun, Haoran;DiMagno, Stephen G.. And the article was included in Angewandte Chemie, International Edition in 2006.Safety of 3,6-Difluoropyridazine This article mentions the following:
The use of anhydrous tetrabutylammonium fluoride in nucleophilic aromatic substitution reactions, including variants of the selective halogen-exchange and fluorodenitration processes, was investigated. It was shown that TBAF permits these reactions to be performed under surprisingly mild conditions if it is used in relatively nonpolar media. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Safety of 3,6-Difluoropyridazine).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. The pyridazine structure is also found within the structure of several drugs such as cefozopran, cadralazine, minaprine, pipofezine, and hydralazine. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Safety of 3,6-Difluoropyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem