Synthesis and evaluation of pyrazolo[1,5-b]pyridazines as selective cyclin dependent kinase inhibitors was written by Stevens, Kirk L.;Reno, Michael J.;Alberti, Jennifer B.;Price, Daniel J.;Kane-Carson, Laurie S.;Knick, Victoria B.;Shewchuk, Lisa M.;Hassell, Anne M.;Veal, James M.;Davis, Stephen T.;Griffin, Robert J.;Peel, Michael R.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2008.Recommanded Product: 19064-65-4 This article mentions the following:
A novel series of pyrazolo[1,5-b]pyridazines have been synthesized and identified as cyclin dependent kinase inhibitors potentially useful for the treatment of solid tumors. Modification of the hinge-binding amine or the C(2)- and C(6)-substitutions on the pyrazolopyridazine core provided potent inhibitors of CDK4 and demonstrated enzyme selectivity against VEGFR-2 and GSK3β. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 19064-65-4).
3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine and derivatives coordinate readily with transition metals to form complexes and catalysts with synthetic utility.Recommanded Product: 19064-65-4
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem