Mason, S. F. et al. published their research in Journal of the Chemical Society in 1958 | CAS: 19064-65-4

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine

The tautomerism of N-heteroaromatic hydroxy compounds. III. Ionization constants was written by Mason, S. F.. And the article was included in Journal of the Chemical Society in 1958.Category: pyridazine This article mentions the following:

Acidic and basic ionization constants are reported for a number of N-heteroaromatic hydroxy compounds and their O- and N-Me derivatives From the measured and from published values, tautomeric equilibrium constants (Kt = [NH form]/[OH form]) were estimated for the monoaza compounds, and for the diaza compounds with not more than one N atom conjugated with the OH group. For the diazacompds. with a ring-N atom placed both ortho and para to the OH group, the equilibrium constant (Kop = [ο-quinonoid NH form]/[p-quinonoid NH form]) was similarly estimated Such constants agree, to within an order of magnitude, with those determined spectrophotometrically. The ionization and tautomeric constants vary with the π-electron energies of the species in equilibrium Absorption spectra were measured with a Hilger Uvispek H700/305 Quartz Spectrophotometer, and aqueous solutions with pH values 2 units less than pK1 value of the 63 compounds examined Ionization constants were determined by potentiometric titration at 20° under N, a Cambridge pH meter being used with glass and calomel electrodes. The ionization constants of the N-heteroaromatic hydroxy compounds were measured at 0.004M and those of the O- and N-Me derivatives at 0.01M. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Category: pyridazine).

3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem