Identification of N-(1H-pyrazol-4-yl)carboxamide inhibitors of interleukin-1 receptor associated kinase 4: Bicyclic core modifications was written by Lim, Jongwon;Altman, Michael D.;Baker, James;Brubaker, Jason D.;Chen, Hongmin;Chen, Yiping;Kleinschek, Melanie A.;Li, Chaomin;Liu, Duan;MacLean, John K. F.;Mulrooney, Erin F.;Presland, Jeremy;Rakhilina, Larissa;Smith, Graham F.;Yang, Ruojing. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2015.Recommanded Product: 19064-65-4 This article mentions the following:
IRAK4 plays a critical role in the IL-1R and TLR signaling, and selective inhibition of the kinase activity of the protein represents an attractive target for the treatment of inflammatory diseases. A series of permeable N-(1H-pyrazol-4-yl)carboxamides was developed by introducing lipophilic bicyclic cores in place of the polar pyrazolopyrimidine core of 5-amino-N-(1H-pyrazol-4-yl)pyrazolo[1,5-a]pyrimidine-3-carboxamides. Replacement of the pyrazolo[1,5-a]pyrimidine core with the pyrrolo[2,1-f][1,2,4]triazine, the pyrrolo[1,2-b]pyridazine, and thieno[2,3-b]pyrazine cores guided by c Log D led to the identification of highly permeable IRAK4 inhibitors with excellent potency and kinase selectivity. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 19064-65-4).
3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines are rare in nature, possibly reflecting the scarcity of naturally occurring hydrazines, common building blocks for the synthesis of these heterocycles. Pyridazine compounds have attracted interest in various fields like medicinal, industrial, and agricultural research as they are used for numerous biological activities and other applications.Recommanded Product: 19064-65-4
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem