Studies in the field of pyridazine compounds. 20. 6H-1,2,4-Triazino[4,3-b]1,2,4-triazolo[3,4-f]pyridazine, a novel angular ring system was written by Kosary, Judit;Jerkovich, Gyula;Polos, Katalin;Kasztreiner, Endre. And the article was included in Monatshefte fuer Chemie in 1986.Safety of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one This article mentions the following:
The novel ring system, the title triazinotriazolopyridazine I (R = H, Ph; R1 = Me, CH:CHCO2Et, CH:CMeCO2Et) was prepared either by ring closure of ethoxycarbonylethylenetriazolopyridazinylhydrazines II (R2 = H, Me) in polyphosphoric acid or a hydrazine III under the action of tri-Et orthoformate. Compound I (R = H; R1 = CH:CMeCO2Et) showed a pos. inotropic effect. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Safety of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one).
6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Safety of 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem