The tautomeric properties of 6-(2-pyrrolyl)pyridazin-3-one and 6-(2-pyrrolyl)pyridazin-3-thione was written by Jones, R. Alan;Whitmore, Alexander. And the article was included in ARKIVOC (Gainesville, FL, United States) in 2007.Recommanded Product: 19064-65-4 This article mentions the following:
The pyrrolyl substituent enhances the electron densities on the pyridazine ring and has the effect of shifting the positions of the tautomeric equilibrium for 1c,d ⇌ 2c,d, which exist predominantly as the pyridazin-3-one and -3-thione forms, towards the hydroxyl (thiol) structures, compared with those of those for the parent unsubstituted systems. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Recommanded Product: 19064-65-4).
3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Recommanded Product: 19064-65-4
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem