Synthesis and herbicidal activity of 3-(substituted benzyloxy)-6-(substituted amino)pyridazines was written by Hu, Fang-Zhong;Zhang, Min;Zhu, You-Quan;Zou, Xiao-Mao;Liu, Bin;Yang, Hua-Zheng. And the article was included in Youji Huaxue in 2007.Quality Control of 3,6-Difluoropyridazine This article mentions the following:
A series of new 3-(substituted benzyloxy)-6-(substituted amino)pyridazines were synthesized through the reaction of 3-(substituted benzyloxy)-6-fluoropyridazines with the solution of dimethylamine, morpholine or piperidine. The title compounds were identified by IR, 1H NMR spectra and elemental analyses. Preliminary bioassay showed that some of them had certain extent herbicidal activities, and the structure-activity relationship was also discussed. In the experiment, the researchers used many compounds, for example, 3,6-Difluoropyridazine (cas: 33097-39-1Quality Control of 3,6-Difluoropyridazine).
3,6-Difluoropyridazine (cas: 33097-39-1) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Quality Control of 3,6-Difluoropyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem