Cooperative Interactions in the Second Coordination Sphere of Pyridazine/Pyridine Containing Polyazaheterocyclic Iron(II) Complexes Favor Protonation was written by Hammoud, Ahmad;Nshimyumuremyi, Jean-Boris;Bourotte, Jeremie;Lucaccioni, Fabio;Robeyns, Koen;Dirtu, Marinela M.;Garcia, Yann;Singleton, Michael L.. And the article was included in European Journal of Inorganic Chemistry in 2018.Reference of 27349-66-2 This article mentions the following:
The new pyridazine containing iron complexes, [N,N,N’,N’-tetrakis(3-pyridazylmethyl)propylenediamine]iron(II)(PF6)2 (1) and [N,N’-bis(2-pyridazylmethyl)-N,N’-bis(2-pyridylmethyl)propylenediamine]iron(II) (PF6)2 (2) were synthesized and their reactivity towards protonation was compared to that of the analogous tetrapyridine complex [N,N,N’,N’-tetrakis(2-pyridylmethyl)propylenediamine]iron(II)(PF6)2 (3). The solution and solid-state structures were confirmed by NMR and x-ray crystallog. studies. For 1–3, the ligands bind in a hexadentate fashion giving similar octahedral structures with an N6 coordination environment. Across the series, the increasing number of pyridazines has only modest effects on the spectroscopic and electrochem. properties of the metal. Nevertheless, their reactivity towards protonation is drastically different. While 2 and 3 decompose in the presence of strong acids, 1 is able to be stably protonated as a result of cooperative 2nd sphere interactions. In the experiment, the researchers used many compounds, for example, 3-(Chloromethyl)pyridazine hydrochloride (cas: 27349-66-2Reference of 27349-66-2).
3-(Chloromethyl)pyridazine hydrochloride (cas: 27349-66-2) belongs to pyridazine derivatives. Pyridazine and phthalazine have quite different spectroscopic properties compared with their isomers, pyrazine and quinoxaline. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Reference of 27349-66-2
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem