Acidity study on some pyridazines was written by Gueven, Alaettin. And the article was included in Journal of Molecular Structure: THEOCHEM in 2004.Safety of 3-Methoxypyridazine This article mentions the following:
The tautomeric, conformational equilibrium positions, and pKa values of some pyridazine derivatives 1-17 have been examined by means of semiempirical AM1 COSMO calculations in aqueous solution (ε=78.4). The results obtained from the calculations have been compared with the exptl. findings. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Safety of 3-Methoxypyridazine).
3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. The pyridazine structure is a popular pharmacophore which is found within a number of herbicides such as credazine, pyridafol and pyridate. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Safety of 3-Methoxypyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem