Asymmetric Cu-Catalyzed 1,4-Dearomatization of Pyridines and Pyridazines without Preactivation of the Heterocycle or Nucleophile was written by Gribble, Michael W.;Guo, Sheng;Buchwald, Stephen L.. And the article was included in Journal of the American Chemical Society in 2018.SDS of cas: 19064-65-4 This article mentions the following:
A chiral copper hydride (CuH) complex is shown to catalyze C-C bond-forming dearomatization of pyridines and pyridazines at room temperature The catalytic reaction operates directly on free heterocycles and generates the nucleophiles in situ, eliminating the need for stoichiometric preactivation of either reaction partner; further, it is one of very few methods available for the enantioselective 1,4-dearomatization of heteroarenes. Combining the dearomatization with facile derivatization steps enables one-pot syntheses of enantioenriched pyridines and piperidines. In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4SDS of cas: 19064-65-4).
3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazines is a six-membered nitrogen-containing significant heterocycle. It has received considerable interest because of its useful applications as natural products, pharmaceuticals, and various bioactive molecules. Pyridazine is bioavailable (especially in the CNS) and can reduce toxicity. Pyridazine is a component of several drug molecules, and the pyridazine pharmacophore has contributed to a variety of pharmacologically active compounds.SDS of cas: 19064-65-4
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem