Synthesis of new s-triazolo[4,3-b]pyridazines was written by Francavilla, P.;Lauria, F.. And the article was included in Journal of Heterocyclic Chemistry in 1971.Synthetic Route of C5H3ClN4O This article mentions the following:
A new synthesis of s-triazolo[4,3-b]pyridazine (I) derivatives was achieved starting from 3,6-dichloropyridazine. The method opens the way to substitutions in the 2- or 3-positions. A tricyclo derivative, 3-chloro-6-methyl-(bis-s-triazolo[4,3-b;3′,4′-f]pyridazine) (II), was also synthesized. In the experiment, the researchers used many compounds, for example, 6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7Synthetic Route of C5H3ClN4O).
6-Chloro-[1,2,4]triazolo[4,3-b]pyridazin-3(2H)-one (cas: 33050-32-7) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The activity depends upon the changes of substituted groups in the pyridazine ring system resulting in different biological activities. In addition, the natural pyrimidine bases uracil, thymine, and cytosine, which are constituents of the nucleic acids, are found to be the most important naturally occurring diazines.Synthetic Route of C5H3ClN4O
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem