Tautomerism of N-heterocycles. II. 3-Hydroxypyridazin-6-one and 3-mercaptopyridazine-6-thione was written by Barlin, Gordon B.. And the article was included in Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry (1972-1999) in 1974.Synthetic Route of C5H6N2O This article mentions the following:
The ionization constants and uv of 3,6-dimercaptopyridazine and its N-Me and S-Me derivatives indicated that the parent compound existed as 3-mercaptopyridazine-6-thione in aqueous solution; 3,6-dihydroxypyridazine, its N,N-di-Me derivative, and 3-hydroxypyridazine behaved abnormally on protonation, owing to the existence of 2 overlapping ionization constants In the experiment, the researchers used many compounds, for example, 3-Methoxypyridazine (cas: 19064-65-4Synthetic Route of C5H6N2O).
3-Methoxypyridazine (cas: 19064-65-4) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. The unsubstituted pyridazines are more resistant to eletrophilic substitution due to the nature of withdrawal of electron density from the ring by two heteroatoms, while the related electron deficiency of the ring makes pyridazine more easily attacked by nucleophiles.Synthetic Route of C5H6N2O
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem