Month: November 2022

Heinisch, Gottfried published the artcilePyridazines. 7. Preparation of pyridazine-3-carboxaldehyde: synthesis and reactivity studies, Formula: C5H4N2O, the publication is Monatshefte fuer Chemie (1977), 108(1), 213-24, database is CAplus.

MnO2-oxidation of 3-pyridazinemethanol gave 3-pyridazinecarboxaldehyde (I). Properties of I and its reactions with NH compounds and methylpiridazines were studied. Reaction of I with 3-methylpiridazine gave mainly products of aldol addition II and III. Elimination of H2O from II gave the alkene IV. Isolation of dipyridazinylethane V as main product of reaction of I with 4-methylpiperazine however shows, that thermally induced dismutation cannot be excluded also on pyridazinyl-3-carbinols.

Monatshefte fuer Chemie published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Formula: C5H4N2O.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Heinisch, Gottfried published the artcileSyntheses and reactions of pyridazine derivatives, VI. 1,2-Dipyridazinylethene- and -ethane-1,2-diols from pyridazine carboxaldehydes, Safety of Pyridazine-4-carbaldehyde, the publication is Monatshefte fuer Chemie (1976), 107(3), 799-808, database is CAplus.

Treatment of pyridazine-4-carboxaldehyde with catalytic amounts of KCN gave pyridazine-4-carboxylic acid and two stereoisomeric diols I, II. Pyridazine-3-carboxaldehyde reacts with HCN to give III. HCN-elimination from III yields the enediol IV which is oxidized to pyridazine-3-carboxylic acid or its methyl ester.

Monatshefte fuer Chemie published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Safety of Pyridazine-4-carbaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Heinisch, G. published the artcileSyntheses and reactions of pyridazine derivatives. 3. Pyridazine-4-carboxaldehyde, Computed Properties of 50901-42-3, the publication is Monatsh. Chem. (1973), 104(5), 1372-82, database is CAplus.

4-Pyridazine-carboxaldehyde (I) was prepared by treating 4-methylpyridazine with PhCHO and OsO4 oxidation of the resulting 4-styrylpyridazine. I underwent a variety of reactions with amines and CH-acids, as well as the Cannizzaro reaction.

Monatsh. Chem. published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Computed Properties of 50901-42-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Heinisch, G. published the artcileSyntheses and reactions of pyridazine derivatives. V. Thermal disproportionation of pyridazinyl-4-carbinols, Safety of Pyridazine-4-carbaldehyde, the publication is Monatshefte fuer Chemie (1974), 105(4), 763-71, database is CAplus.

Pyridazinecarbinols I (R1 = Me, Ph, 4-pyridazinylmethyl) disproportionated at 120° into the ketones II and alkanes III. The mechanism of the disproportionation was discussed. I (R1 = 4-pyridazinylmethyl) was prepared by treating 4-methylpyridazine with Et 4-pyridazinecarboxylate and Me3COK and reducing II (R1 = 4-pyridazinylmethyl). SeO2 oxidation of III (R1 = 4-pyridazinylmethyl) gave trans-1,2-bis(4-pyridazinyl)ethene. Condensation of 4-formylpyridazine with acetone gave 1-(4-pyridazinyl)-1,3-butanedione.

Monatshefte fuer Chemie published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Safety of Pyridazine-4-carbaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Piras, Sandra published the artcileSynthesis and evaluation of gastroprotective activity of omeprazole-related benzimidazole, imidazo[4,5-b]pyridine and quinoxaline 2-substituted derivatives, Safety of (6-Methoxypyridazin-3-yl)methanol, the publication is Farmaco (1993), 48(9), 1249-59, database is CAplus and MEDLINE.

Twenty title compounds, bearing either a substituted arylmethylmercapto group or an arylmethylsulfinyl group in position 2, were prepared (general methods given) in order to evaluate their antiulcer and gastroprotective activity in rats with a ligated pylorus, in comparison with omeprazole (50 mg/kg, i.m.). Approx. one-third of these compounds had a moderate activity, being about half as potent as omeprazole. Some structure-activity parameters are briefly discussed.

Farmaco published new progress about 89532-79-6. 89532-79-6 belongs to pyridazine, auxiliary class Pyridazine,Alcohol,Ether, name is (6-Methoxypyridazin-3-yl)methanol, and the molecular formula is C6H8N2O2, Safety of (6-Methoxypyridazin-3-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Berlin, Michael published the artcileReduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists, Application of Pyridazine-4-carbaldehyde, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2359-2364, database is CAplus and MEDLINE.

Structural features of the substituted 4-piperidinyl urea analogs, e.g., I, responsible for the H3 antagonist activity, have been identified. Structure-activity relationship of the H3 receptor affinity, hERG ion channel inhibitory activity and their separation is described. Preliminary pharmacokinetic evaluation of some of the compounds of the series is addressed.

Bioorganic & Medicinal Chemistry Letters published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Application of Pyridazine-4-carbaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Heinisch, Gottfried published the artcilePyridazines. 77. Synthetic building blocks containing the 1,2-diazine moiety: N- and O-protected 3-(4-pyridazinyl)isoserines, COA of Formula: C5H4N2O, the publication is Heterocycles (1996), 43(5), 1057-1072, database is CAplus.

The syntheses of pyridazinylglycidates and pyridazinylimines as potential precursors of pyridazinylisoserine derivatives is described. Reactions of the imines I (R = PhCH₂, p-MeOC₆H₄) with α-silyloxyketene acetals, TBDMSOCH:C(OEt)OTBDMS (TBDMS = Me₃CSiMe₂), in the presence of zinc chloride led to isoserine derivatives II. The mixtures of diastereoisomers obtained were separated and configurations were determined by x-ray anal.

Heterocycles published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, COA of Formula: C5H4N2O.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Chheda, Pratik R. published the artcileOne-Pot Reductive Alkylation of 2,4-Dihydroxy Quinolines and Pyridines, Computed Properties of 50901-42-3, the publication is Journal of Organic Chemistry (2021), 86(10), 7148-7162, database is CAplus and MEDLINE.

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

Journal of Organic Chemistry published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Computed Properties of 50901-42-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Heinisch, Gottfried published the artcilePyridazines. Part 13. Substitution of the 1,2-diazine system with sym-trioxanyl radicals; a route to pyridazinecarbaldehydes, COA of Formula: C5H4N2O, the publication is Journal of Heterocyclic Chemistry (1980), 17(7), 1501-4, database is CAplus.

Pyridazine and 3-methylpyridazine were selectively attacked by sym-trioxanyl radicals at C-4 and/or C-5, but 4-methylpyridazine reacts under similar conditions to give not only the C-5 substitution product but also 3- and/or 6-trioxanylsubstituted methylpyridazines. Some of the reaction products were hydrolyzed to the formylmethylpyridazines.

Journal of Heterocyclic Chemistry published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, COA of Formula: C5H4N2O.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem

Kosary, Judit published the artcileStudies of pyridazine-ring-containing compounds. 17. Synthesis of 6-methoxypyridazine-3-carboxaldehyde, HPLC of Formula: 89532-79-6, the publication is Magyar Kemiai Folyoirat (1983), 89(12), 567-8, database is CAplus.

The method of T. Nakagome (1962) for preparation of the title compound I was improved. 3-Methyl-6-chloropyridazine, purified on a Silica Gel 60 column, was oxidized with H₂O₂ to give 56% 3-methyl-6-chloropyridazine 2-oxide, which was methoxylated with NaOMe to give 90% 3-methyl-6-methoxypyridazine 2-oxide. Acetylation of the latter gave 78% (6-methoxy-3-pyridazinylmethyl)acetate which was heated with 10% HCl to give 87% 6-methoxypyridazine-6-methanol. Subsequent oxidation with MnO₂ gave 63% I. Alternatively, the oxidation was carried out with SeO₂ (65% yield). I was converted into 6-methoxy[1,2,3]triazolo[1,5-b]pyridazine (II) by the method of J. Kosari (1980).

Magyar Kemiai Folyoirat published new progress about 89532-79-6. 89532-79-6 belongs to pyridazine, auxiliary class Pyridazine,Alcohol,Ether, name is (6-Methoxypyridazin-3-yl)methanol, and the molecular formula is C6H8N2O2, HPLC of Formula: 89532-79-6.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem