Sitamze, Jean Marie et al. published their research in Journal of Organic Chemistry in 1992 | CAS: 105537-97-1

5-Phenylpyridazin-3-amine (cas: 105537-97-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Category: pyridazine

A general and convenient synthesis of 3-aminopyridazines was written by Sitamze, Jean Marie;Schmitt, Martine;Wermuth, Camille Georges. And the article was included in Journal of Organic Chemistry in 1992.Category: pyridazine The following contents are mentioned in the article:

Hydrogenolysis of 3-hydrazinopyridazines I (R = H, Ph, 4-MeOC6H4; R1 = H, Me, Pr, Ph; R2 = H, Me, Et, CHMe2, CH2Ph, CH2CH2Ph; R3 = NHNH2) by means of nickel-aluminum alloy in alk. medium yield the corresponding 3-aminopyridazines I (R3 = NH2) in approx. 80 % yield. This study involved multiple reactions and reactants, such as 5-Phenylpyridazin-3-amine (cas: 105537-97-1Category: pyridazine).

5-Phenylpyridazin-3-amine (cas: 105537-97-1) belongs to pyridazine derivatives. Pyridazine-based compounds continued to be a great source of biologically active compounds as evidenced by the number of publications which emerged in 2021. Pyridazine can act as a hydrogen bond acceptor to improve the physicochemical properties of drug molecules by increasing their water solubility, and has a high affinity for complexing with targets due to its dipole moment.Category: pyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem