Vetrichelvan, Muthalagu published the artcileDevelopment of a Scalable Synthesis of the Small Molecule TGFβR1 Inhibitor BMS-986260, Product Details of C18H12ClFN6O, the publication is Organic Process Research & Development (2020), 24(7), 1310-1320, database is CAplus.
A scalable route to the small mol. TGFβR1 inhibitor BMS-986260 I was developed. This alternative approach circumvented the purification of intermediates by column chromatog. and provided access to multikilogram quantities of the key intermediate, 6-formylimidazo[1,2-b]pyridazine-3-carbonitrile. The safety aspects of the synthetic approach to the other fragment of the API (TosMIC) were critically evaluated, and a robust process for its large-scale synthesis was successfully demonstrated.
Organic Process Research & Development published new progress about 2001559-19-7. 2001559-19-7 belongs to pyridazine, auxiliary class TGF-beta/Smad,TGF-beta Receptor, name is 6-(4-(3-Chloro-4-fluorophenyl)-1-(2-hydroxyethyl)-1H-imidazol-5-yl)imidazo[1,2-b]pyridazine-3-carbonitrile, and the molecular formula is C10H10O6, Product Details of C18H12ClFN6O.
Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem