Chheda, Pratik R.’s team published research in Journal of Organic Chemistry in 86 | CAS: 50901-42-3

Journal of Organic Chemistry published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Computed Properties of 50901-42-3.

Chheda, Pratik R. published the artcileOne-Pot Reductive Alkylation of 2,4-Dihydroxy Quinolines and Pyridines, Computed Properties of 50901-42-3, the publication is Journal of Organic Chemistry (2021), 86(10), 7148-7162, database is CAplus and MEDLINE.

A one-pot, Hantzsch ester-mediated Knoevenagel condensation-reduction reaction has been developed for alkylation of a wide range of substituted 2,4-quinoline diols and 2,4-pyridine diols with aldehydes. The process is operationally simple to perform, scalable, and provides highly useful C-3 alkylated quinoline and pyridine diols in yields of 58-92%. The alkylation products can be converted to 2,4-dihaloquinoline and pyridine substrates for further functionalization.

Journal of Organic Chemistry published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Computed Properties of 50901-42-3.

Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem