Berlin, Michael published the artcileReduction of hERG inhibitory activity in the 4-piperidinyl urea series of H3 antagonists, Application of Pyridazine-4-carbaldehyde, the publication is Bioorganic & Medicinal Chemistry Letters (2010), 20(7), 2359-2364, database is CAplus and MEDLINE.
Structural features of the substituted 4-piperidinyl urea analogs, e.g., I, responsible for the H3 antagonist activity, have been identified. Structure-activity relationship of the H3 receptor affinity, hERG ion channel inhibitory activity and their separation is described. Preliminary pharmacokinetic evaluation of some of the compounds of the series is addressed.
Bioorganic & Medicinal Chemistry Letters published new progress about 50901-42-3. 50901-42-3 belongs to pyridazine, auxiliary class Pyridazine,Aldehyde, name is Pyridazine-4-carbaldehyde, and the molecular formula is C5H4N2O, Application of Pyridazine-4-carbaldehyde.
Referemce:
https://en.wikipedia.org/wiki/Pyridazine,
Pyridazine | C4H4N2 – PubChem