Month: October 2022

《An Activity-Based Probe Targeting Non-Catalytic, Highly Conserved Amino Acid Residues within Bromodomains》 was published in Angewandte Chemie, International Edition in 2019. These research results belong to D’Ascenzio, Melissa; Pugh, Kathryn M.; Konietzny, Rebecca; Berridge, Georgina; Tallant, Cynthia; Hashem, Shaima; Monteiro, Octovia; Thomas, Jason R.; Schirle, Markus; Knapp, Stefan; Marsden, Brian; Fedorov, Oleg; Bountra, Chas; Kessler, Benedikt M.; Brennan, Paul E.. Product Details of 53085-52-2 The article mentions the following:

Bromodomain-containing proteins are epigenetic modulators involved in a wide range of cellular processes, from recruitment of transcription factors to pathol. disruption of gene regulation and cancer development. Since the druggability of these acetyl-lysine reader domains was established, efforts were made to develop potent and selective inhibitors across the entire family. Here we report the development of a small mol.-based approach to covalently modify recombinant and endogenous bromodomain-containing proteins by targeting a conserved lysine and a tyrosine residue in the variable ZA or BC loops. Moreover, the addition of a reporter tag allowed in-gel visualization and pull-down of the desired bromodomains. The experimental part of the paper was very detailed, including the reaction process of 6-Chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine(cas: 53085-52-2Product Details of 53085-52-2)

6-Chloro-3-methyl-[1,2,4]triazolo[4,3-b]pyridazin-8-amine(cas: 53085-52-2) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Product Details of 53085-52-2

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Yamagami, Chisako; Takao, Narao; Fujita, Toshio published their research in Quantitative Structure-Activity Relationships on December 31 ,1990. The article was titled 《Hydrophobicity parameter of diazines. 1. Analysis and prediction of partition coefficients of monosubstituted diazines》.Quality Control of 3-Ethoxypyridazine The article contains the following contents:

The octanol/water partition coefficient (P) of a number of monosubstituted diazines was measured. The composition of the π value of substituents, the increment in the log P value accompanying the introduction of substituents, was examined in terms of physicochem. substituent parameters and correlation anal. The diazine-π value of substituents was generally higher than the pyridine-π value of corresponding substituents, indicating that the intramol. electronic interactions between the ring-N atoms and substituent are more pronounced than those in substituted pyridines in governing the log P value of the mol. Except for 2-substituted pyrimidines, the π value of substituents in each series of monosubstituted diazines was in general nicely correlated with the π value of the corresponding substituents in substituted pyridines along with electronic parameter terms representing bidirectional electronic effects on the relative solvation of the ring-N atom(s) and the hydrogen-bondable substituents with partitioning solvents according to the procedure proposed previously for the anal. of the π value in disubstituted benzenes and monosubstituted pyridines. Keeping in mind that 2-pyrimidines substituted by hydrogen-bondable groups sometimes behave as outliers, the correlations were believed to be usable for prediction of log P values of monosubstituted diazines. In the experiment, the researchers used many compounds, for example, 3-Ethoxypyridazine(cas: 62567-44-6Quality Control of 3-Ethoxypyridazine)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Quality Control of 3-Ethoxypyridazine

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

《Synthesis, reactions, and spectroscopy of 3-benzoyl-6-phenylpyridazines of expected biological activity》 was written by Issac, Yvette A.. Recommanded Product: 40020-05-1 And the article was included in Zeitschrift fuer Naturforschung, B: Chemical Sciences on August 31 ,1999. The article conveys some information:

Oxidative decyanation of α,6-diphenyl-3-pyridazineacetonitrile in MeOH yielded 3-benzoyl-6-phenylpyridazine (I). α,6-Diphenyl-3-pyridazinemethanol was obtained via NaBH4 reduction of I. Reaction of I with NH2OH or its O-alkyl derivatives yields 3-benzoyl-6-phenylpyridazine oxime (II) and alkyloximes, resp. Treatment of II with AcOH/H2SO4 afforded I again and not the rearranged products. Beckmann rearrangement was achieved for II and the corresponding ethyloxime giving solely 3-carboxanilide-6-phenylpyridazine. 4-Benzoyl-3-phenyl-6-chloropyridazine oxime was synthesized from the corresponding ketone. The results came from multiple reactions, including the reaction of 4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1Recommanded Product: 40020-05-1)

4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, vasodilator, antiarrhythmic, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, neuroleptic, sedative-hypnotic, anticonvulsant, immunosuppressant, cardiotonic, and hypocholesterolaemic. Recommanded Product: 40020-05-1

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

SDS of cas: 62567-44-6On October 21, 1995 ,《A regiospecific reaction of pyridazines with vicarious nucleophilic substitution via their dicyanomethylide derivatives》 was published in Journal of the Chemical Society, Chemical Communications. The article was written by Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Okada, Mamiko; Ohsawa, Akio. The article contains the following contents:

The phenyl(or p-tolyl)sulfonylmethyl group is introduced with complete regiospecificity to the C-4 position of 3-substituted pyridazines using vicarious nucleophilic substitution of pyridazinium dicyanomethylides. In the experiment, the researchers used many compounds, for example, 3-Ethoxypyridazine(cas: 62567-44-6SDS of cas: 62567-44-6)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.SDS of cas: 62567-44-6

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem

Recommanded Product: 62567-44-6On May 21, 1998 ,《Vicarious nucleophilic substitution of pyridazinium N-dicyanomethylides》 appeared in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. The author of the article were Itoh, Takashi; Matsuya, Yuji; Nagata, Kazuhiro; Miyazaki, Michiko; Tsutsumi, Nozomi; Ohsawa, Akio. The article conveys some information:

Pyridazines have been allowed to react with tetracyanoethylene oxide to give pyridazinium N-dicyanomethylides, which are subjected to vicarious nucleophilic substitution to afford the corresponding 4-substituted derivatives in moderate to good yields. The dicyanomethylene group is readily eliminated by a radical reaction, and 4-substituted pyridazines are obtained. The results came from multiple reactions, including the reaction of 3-Ethoxypyridazine(cas: 62567-44-6Recommanded Product: 62567-44-6)

3-Ethoxypyridazine(cas: 62567-44-6) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Recommanded Product: 62567-44-6

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem