Product Details of 5788-60-3On May 31, 2015, Kim, Chaewon; Lee, Jihee; Park, Myung-Sook published an article in Archives of Pharmacal Research. The article was 《Synthesis of new diorganodiselenides from organic halides: their antiproliferative effects against human breast cancer MCF-7 cells》. The article mentions the following:
A new series of bis(aryl or aralkyl) diselenides was synthesized by selenylation from aryl halide (or aralkyl halide) for development of new anticancer agents. The process involves the reaction of aryl halides (or aralkyl halides) with selenium, hydrazine hydrate under atm. pressure in the presence of sodium hydroxide, to afford diorganodiselenides. These new compounds showed antiproliferative activities against breast cancer (MCF-7) cells in CCK-8 assays, and could be promising candidates for chemotherapy of carcinomas. Among 17 synthesized compounds for inhibiting the growth of these cell lines, 1,2-bis(chloropyridazinyl) diselenide I showed the highest potency. This result suggests the potential anticancer activity of compound I. The experimental process involved the reaction of 3-Chloro-6-propoxypyridazine(cas: 5788-60-3Product Details of 5788-60-3)
3-Chloro-6-propoxypyridazine(cas: 5788-60-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Product Details of 5788-60-3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem