Fulep, Gunther’s team published research in Molecules [Electronic Publication] in 1998 | CAS: 1445-56-3

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Synthetic Route of C5H2ClN3

In 1998,Molecules [Electronic Publication] included an article by Fulep, Gunther; Haider, Norbert. Synthetic Route of C5H2ClN3. The article was titled 《Synthesis and intramolecular [4+2] cycloaddition reactions of 4-pyridazinecarbonitriles with alkyne side chains》. The information in the text is summarized as follows:

Title compounds I (X = O, R = H, Me; X = NH, R = H) were prepared I underwent thermally induced intramol. Diels-Alder reactions with inverse electron demand, affording fused benzonitriles (II). Incorporation of a 1,2-phenylene unit into the side chain, as in III (X = O, NAc), resulted in a more favorable conformation of the dienophilic substructure and thus in a pronounced acceleration of the [4+2] cycloaddition reaction. In the experiment, the researchers used 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Synthetic Route of C5H2ClN3)

3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Synthetic Route of C5H2ClN3

Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem