Safety of 3-Chloropyridazine-4-carbonitrileOn May 31, 1991, Czech, Karin; Haider, Norbert; Heinisch, Gottfried published an article in Monatshefte fuer Chemie. The article was 《Pyridazines. LIV. The synthesis of pyridazine-fused S-heterocycles: thieno[2,3-c]pyridazine, pyrimido[4′,5′:4,5]thieno[2,3-c]pyridazine, and pyridazino[3,4-b][1,4]benzothiazine》. The article mentions the following:
Starting from 3-chloro-4-pyridazinecarbonitrile (I), the thienopyridazine derivatives II (R = OMe; R1 = OMe, NH2) were prepared Condensation of II (R = NH2) with (EtO3)CH afforded the novel tricyclic system III. Reaction of I (R = R1 = NH2) with 2-H2NC6H4SH, followed by treatment with NaH/DMSO gave pyridazinobenzothiazine IV instead of the expected condensed thiazepine. In the experiment, the researchers used many compounds, for example, 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Safety of 3-Chloropyridazine-4-carbonitrile)
3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Safety of 3-Chloropyridazine-4-carbonitrile
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem