Terekhova, M. I.; Petrov, E. S.; Mikhaleva, M. A.; Shkurko, O. P.; Mamaev, V. P.; Shatenshtein, A. I. published the artcile< Effects of aza groups on the NH acidity of aminoazines and CH acidity of acetylazines>, Related Products of 20744-39-2, the main research area is acidity aminoazine acetylazine aza effect; solvent effect acidity aminoazine.
The NH and CH acidities (pKNH and pKCH, resp.) of RNH2 (I; R = Ph; 2-, 3-, 4-pyridyl; 3-, 4-pyridazinyl; 2-, 4-, 5-pyrimidinyl; 2-pyrazinyl; s-triazin-2-yl) and RCOMe (II, same R) were analyzed. A N atom in position 2, 3, or 4 relative to the NH2 group of I lowered the pKNH value by 3.1, 2.4, and 4.5, resp.; similarly, the pKCH value of II was lowered by 3.5, 2.9, and 4.8, resp. The effects were additive in most cases. The relation pKNH = 0.89 pKCH + 8.7 was found. The differentiating effect of H2O, compared to Me2SO, on the pKNH values of I was attributed to H bonding with the ring N atoms.
Zhurnal Organicheskoi Khimii published new progress about Acidity. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Related Products of 20744-39-2.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem