Olesen, Preben H.; Kappe, Thomas; Becher, jan published their research in Journal of Heterocyclic Chemistry on December 31 ,1988. The article was titled 《Pyridazines with heteroatom substituents in position 3 and 5. 2. Regioselective introduction of mercapto groups in pyridazines》.Application In Synthesis of 4,6-Dichloro-3-phenylpyridazine The article contains the following contents:
The nucleophilic substitution of halogen in 3,5-dichloro-6-phenylpyridazine (I), 5-chloro-2-methyl-6-phenylpyridazin-3(2H)-one (II, R = Cl, R1 = Me, X = O) and 3-chloro-2-methyl-6-phenylpyridazin-5(2H)-one (III, R = Cl, R1 = Me) with MeONa, EtONa, and Me3CSNa is described. In the last type of compounds, the Me3CS groups can be eliminated regioselectively with Lewis acids, resulting in the formation of monomercapto and monothiopyridazines II (R = SH, R1 = H, Me, X = O, S) and III (R = SH, R1 = H, Me). After reading the article, we found that the author used 4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1Application In Synthesis of 4,6-Dichloro-3-phenylpyridazine)
4,6-Dichloro-3-phenylpyridazine(cas: 40020-05-1) belongs to pyridazine. The pyridazine moiety is an important structural feature of various pharmacologically important compounds with activities like antimicrobial, analgesic, anti-inflammatory, antiplatelet, anticancer, antisecretory, antiulcer, antidepressant, neuroleptic, sedative-hypnotic, anticonvulsant, immunosuppressant, cardiotonic, vasodilator, antiarrhythmic, and hypocholesterolaemic. Application In Synthesis of 4,6-Dichloro-3-phenylpyridazine
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem