Klempier, Norbert; De Raadt, Anna; Griengl, Herfried; Heinisch, Gottfried published their research in Journal of Heterocyclic Chemistry on February 29 ,1992. The article was titled 《Enzymic hydrolysis of heterocyclic nitriles》.Computed Properties of C5H2ClN3 The article contains the following contents:
Chemoselective hydrolysis of heterocyclic nitriles can be achieved by an easy to use immobilized biocatalyst prepared from Rhodococcus sp. Pyrimidine-2-carbonitrile and 3-chloropyridazine-4-carbonitrile were converted into the corresponding amides, while 2-ethoxycarbonyl-4-pyridinecarbonitrile, 6-methylpyridazine-3-carbonitrile, 3-chloropyridazine-4-carbonitrile, 3-ethoxycarbonyl-4,5-dihydroisoxazole-5-carbonitrile, indole-3-carbonitrile, and indole-3-acetonitrile were hydrolyzed to the acids. In addition to this study using 3-Chloropyridazine-4-carbonitrile, there are many other studies that have used 3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Computed Properties of C5H2ClN3) was used in this study.
3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Computed Properties of C5H2ClN3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem