The author of 《Mesoionic pyridazine ribonucleosides. A novel biologically active nucleoside metabolite》 were Bambury, Ronald E.; Feeley, Daniel T.; Lawton, Gerald C.; Weaver, John M.; Wemple, James. And the article was published in Journal of Medicinal Chemistry in 1984. Formula: C5H2ClN3 The author mentioned the following in the article:
Ribofuranosylpyridazinium I was prepared from 4-cyano-3(2H)-pyridazinone (II) by using a low-temperature, kinetically controlled, silyl Hilbert-Johnson reaction followed by deblocking of the resulting triacetate derivative with NaHCO3 in MeOH. I is a urine metabolite of II in mice. I possesses Gram-neg. antibacterial activity in vivo against a systemic Escherichia coli infection in mice with an ED50 of 25-50 mg/kg. A series of 4-substituted 3-oxidopyridazinium ribonucleosides were synthesized as analogs of I. 4-Chloro-3-oxido-1-β-D-ribofuranoylpyridazinium was several times more active than I against E. coli in vitro although it showed no in vivo activity.3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3Formula: C5H2ClN3) was used in this study.
3-Chloropyridazine-4-carbonitrile(cas: 1445-56-3) belongs to pyridazine derivatives.The pyridazine derivatives are mostly present in biologically active compounds and are also present with different pharmacophores. Pyridazines are also important because of their utility in synthetic organic chemistry and in physical organic chemistry.There are reports available for the synthesis of pyridazine and their derivatives by using 2-oxoaldehyes.Formula: C5H2ClN3
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem