Wetzel, B.; Woitun, E.; Reuter, W.; Maier, R.; Lechner, U.; Goeth, H.; Werner, R. published the artcile< Pyrimidinylureidopenicillins. Synthesis and structure-activity relationships>, Safety of Pyridazin-4-amine, the main research area is pyrimidylureidopenicillin preparation bactericide activity; condensation amoxicillin aminopyrimidine; penicillin pyrimidylureido.
The ureidopenicillin VX-VC 43 (I), prepared from the aminopyrimidine II by cyclization and condensation with amoxicillin and Et3N, showed outstanding in vitro and potent in vivo activity in mice. The mean minimal inhibitory concentrations of I against 59 strains of Pseudomonas aeruginosa, 50 strains of Escherichia coli, Klebsiella, and Enterobacter cloacae were 0.62, 0.16, 3.28, and 0.92 μg/mL, resp. The antimicrobial activity of 18 other heterocyclic substituted ureidopenicillins is also reported.
Special Publication – Royal Society of Chemistry published new progress about Condensation reaction. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Safety of Pyridazin-4-amine.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem