Heinisch, G.; Matuszczak, B.; Pachler, S.; Rakowitz, D. published the artcile< The inhibitory activity of diazinyl-substituted thiourea derivatives on human immunodeficiency virus type 1 reverse transcriptase>, Safety of Pyridazin-4-amine, the main research area is diazinylthiourea preparation HIV1 reverse transcriptase inhibition.
Starting from 2-(2-aminoethyl)pyridine, a series of N-diazinyl-N’-[2-(2-pyridyl)ethyl]thioureas was prepared via the (2-pyridyl)ethylisothiocyanate and was screened as non-nucleoside human immunodeficiency virus type 1 reverse transcriptase inhibitors. Derivatives bearing a 3-pyridazinyl or a 4-pyrimidinyl moiety turned out to be the most potent compounds However, they exhibited less activity than nevirapine or trovirdine.
Antiviral Chemistry & Chemotherapy published new progress about Antiviral agents. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Safety of Pyridazin-4-amine.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem