Sakai, Taki; Matsumoto, Yotaro; Ishikawa, Minoru; Sugita, Kazuyuki; Hashimoto, Yuichi; Wakai, Nobuhiko; Kitao, Akio; Morishita, Era; Toyoshima, Chikashi; Hayashi, Tomoatsu; Akiyama, Tetsu published the artcile< Design, synthesis and structure-activity relationship studies of novel sirtuin 2 (SIRT2) inhibitors with a benzamide skeleton>, Formula: C4H5N3, the main research area is benzamide derivative preparation SAR sirtuin 2 inhibitor; SIRT2; Sirtuin.
Human sirtuin 2 (SIRT2) is an attractive target mol. for development of drugs to treat neurodegenerative diseases and cancer, because SIRT2 inhibitors have a protective effect against neurodegeneration and an anti-proliferative effect on cancer stem cells. We designed and synthesized a series of benzamide derivatives as SIRT2 inhibitor candidates. Among them, compound (I) showed the most potent SIRT2-inhibitory activity (IC50 = 0.60 μM), with more than 150-fold selectivity over SIRT1 and SIRT3 isoforms (IC50 >100 μM).
Bioorganic & Medicinal Chemistry published new progress about Antitumor agents. 20744-39-2 belongs to class pyridazine, and the molecular formula is C4H5N3, Formula: C4H5N3.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem