Liu, Yu-Xiu; Wei, Deng-Guo; Zhu, Ye-Rong; Liu, Shao-Hua; Zhang, Yong-Lin; Zhao, Qi-Qi; Cai, Bao-Li; Li, Yong-Hong; Song, Hai-Bin; Liu, Ying; Wang, Yong; Huang, Run-Qiu; Wang, Qing-Min published the artcile< Synthesis, Herbicidal Activities, and 3D-QSAR of 2-Cyanoacrylates Containing Aromatic Methylamine Moieties>, Electric Literature of 120276-59-7, the main research area is hetarylmethylaminoacrylate cyano preparation herbicidal; aminoacrylate cyano preparation herbicidal; arylmethylaminoacrylate cyano preparation herbicidal; cyanoacrylate aromatic methylamine preparation herbicidal.
A series of novel 2-cyanoacrylates containing different aromatic rings, e.g. I (R = MeS, Et, Me2CH; R1 = 4-ClC6H4, 6-bromo-3-pyridinyl, 2-ethoxy-5-thiazolyl, etc) were prepared, and their structures were characterized by 1H NMR, elemental anal., and single-crystal X-ray diffraction anal. Their herbicidal activities against four weeds and inhibition of photosynthetic electron transport against isolated chloroplasts (the Hill reaction) were evaluated. Both in vivo and in vitro data showed that the compounds containing benzene, pyridine, and thiazole moieties gave higher activities than those containing pyrimidine, pyridazine, furan, and THF moieties. To further explore the comprehensive structure-activity relationship on the basis of in vitro data, comparative mol. field anal. (CoMFA) was performed, and the results showed that a bulky and electroneg. group around the para-position of the aromatic rings would have the potential for higher activity, which offered important structural insights into designing highly active compounds prior to the next synthesis.
Journal of Agricultural and Food Chemistry published new progress about Herbicides. 120276-59-7 belongs to class pyridazine, and the molecular formula is C5H4Cl2N2, Electric Literature of 120276-59-7.
Referemce:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem