In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Mechanistic study of reversible solid-state melt isomerization of 2-oxindoles to 2-quinolinones and its occurrence in a mass spectrometer, published in 2019-01-05, which mentions a compound: 885272-25-3, mainly applied to oxindole solid state melt isomerization mechanism green chem, Safety of 2-(5-Methoxy-2-oxoindolin-3-yl)acetic acid.
An eco-friendly equilibrated rearrangement of a series of 2-oxo-3-indolyl acetic acids (1) with 2-oxo-1,2,3,4-tetrahydroquinoline-4-carboxylic acid derivatives (2) was investigated through a solid state melt reaction (SSMR). Mechanistic insight into the thermal rearrangement is provided by 13C-isotopic labeling. The standard mass spectra of 1 and 2 were virtually identical preventing their reliable identification. Reversible interconversion of 1 and 2 was evidenced to occur in the inlet system of a mass spectrometer under electron impact conditions. Relative abundances of fragment ions were found to be a function of temperature
After consulting a lot of data, we found that this compound(885272-25-3)Safety of 2-(5-Methoxy-2-oxoindolin-3-yl)acetic acid can be used in many types of reactions. And in most cases, this compound has more advantages.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem