The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran(SMILESS: BrCCOC1CCCCO1,cas:17739-45-6) is researched.Electric Literature of C10H9NO2. The article 《Enantioselective Synthesis of Ozanimod, the Active Pharmaceutical Ingredient of a New Drug for Multiple Sclerosis》 in relation to this compound, is published in European Journal of Organic Chemistry. Let’s take a look at the latest research on this compound (cas:17739-45-6).
We report here a short enantioselective synthesis of Ozanimod (I), a potent modulator of the enzyme Sphingosine-1-phosphate receptor (S1PR), recently approved by FDA and EMA for the treatment of relapsing-remitting multiple sclerosis. Amongst different synthetic approaches explored, we achieved the best result introducing the stereogenic center in the last step through imine asym. transfer hydrogenation (ATH) using Wills’ catalysts. Besides the reduced numbers of enantiomeric purity controls required, this process culminates in an exceptionally high enantioselective reductive amination obtained with com. available tethered Ru catalysts. Starting from com. available 4-cyano-indanone, enantiomerically pure Ozanimod was obtained in 5 steps in 62% overall yield and 99% ee.
When you point to this article, it is believed that you are also very interested in this compound(17739-45-6)Application In Synthesis of 2-(2-Bromoethoxy)tetrahydro-2H-pyran and due to space limitations, I can only present the most important information.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem