So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Caldwell, Charles G.; Chen, Ping; He, Jiafang; Parmee, Emma R.; Leiting, Barbara; Marsilio, Frank; Patel, Reshma A.; Wu, Joseph K.; Eiermann, George J.; Petrov, Aleksandr; He, Huaibing; Lyons, Kathryn A.; Thornberry, Nancy A.; Weber, Ann E. researched the compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride( cas:136725-55-8 ).Application of 136725-55-8.They published the article 《Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitors》 about this compound( cas:136725-55-8 ) in Bioorganic & Medicinal Chemistry Letters. Keywords: cyclohexylglycylfluoropyrrolidine preparation dipeptidyl peptidase IV inhibitor. We’ll tell you more about this compound (cas:136725-55-8).
Amides derived from fluorinated pyrrolidines and 4-substituted cyclohexylglycine analogs have been prepared and evaluated as inhibitors of dipeptidyl dipeptidase IV (DP-IV). Analogs which incorporated (S)-3-fluoropyrrolidine showed good selectivity for DP-IV over quiescent cell proline dipeptidase (QPP). Amide I had good pharmacokinetic properties and was orally active in an oral glucose tolerance test in lean mice.
In addition to the literature in the link below, there is a lot of literature about this compound((R)-(-)-3-Fluoropyrrolidine Hydrochloride)Application of 136725-55-8, illustrating the importance and wide applicability of this compound(136725-55-8).
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem