Synthetic Route of C7H13BrO2. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Enantioselective Synthesis of Ozanimod, the Active Pharmaceutical Ingredient of a New Drug for Multiple Sclerosis. Author is Cianferotti, Claudio; Barreca, Giuseppe; Bollabathini, Venkatesh; Carcone, Luca; Grainger, Damian; Staniland, Samantha; Taddei, Maurizio.
We report here a short enantioselective synthesis of Ozanimod (I), a potent modulator of the enzyme Sphingosine-1-phosphate receptor (S1PR), recently approved by FDA and EMA for the treatment of relapsing-remitting multiple sclerosis. Amongst different synthetic approaches explored, we achieved the best result introducing the stereogenic center in the last step through imine asym. transfer hydrogenation (ATH) using Wills’ catalysts. Besides the reduced numbers of enantiomeric purity controls required, this process culminates in an exceptionally high enantioselective reductive amination obtained with com. available tethered Ru catalysts. Starting from com. available 4-cyano-indanone, enantiomerically pure Ozanimod was obtained in 5 steps in 62% overall yield and 99% ee.
This literature about this compound(17739-45-6)Synthetic Route of C7H13BrO2has given us a lot of inspiration, and I hope that the research on this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem