Computed Properties of C8H9NO3. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: Methyl 5-(hydroxymethyl)picolinate, is researched, Molecular C8H9NO3, CAS is 39977-42-9, about Continuous-Flow Pd-Catalyzed Carbonylation of Aryl Chlorides with Carbon Monoxide at Elevated Temperature and Pressure. Author is Mata, Alejandro; Hone, Christopher A.; Gutmann, Bernhard; Moens, Luc; Kappe, C. Oliver.
The development of a continuous-flow protocol for a palladium-catalyzed methoxycarbonylation of (hetero)aryl chlorides RCl (R = 4-cyanophenyl, quinolin-2-yl, pyrazin-2-yl, etc.) using carbon monoxide gas and methanol is described. (Hetero)aryl chlorides are the least expensive of the aryl halides, but are underutilized in carbonylation reactions due to their very poor reactivity. The described protocol exploits intensified conditions at elevated temperature and pressure, which are readily accessed within a continuous-flow environment, to provide moderate to excellent product yields RC(O)OCH3 (11 examples) in a short 16 min residence time. The continuous-flow protocol enables the safe and potentially scalable carbonylation of aryl chlorides using CO gas.
This literature about this compound(39977-42-9)Computed Properties of C8H9NO3has given us a lot of inspiration, and I hope that the research on this compound(Methyl 5-(hydroxymethyl)picolinate) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem