Tear, Louise R.; Carrera, Carla; Gianolio, Eliana; Aime, Silvio published the article 《Towards an Improved Design of MRI Contrast Agents: Synthesis and Relaxometric Characterisation of Gd-HPDO3A Analogues》. Keywords: MRI contrast agent relaxometry gadolinium HPDO3A analog; MRI contrast agents; gadolinium; lanthanides; macrocycles; relaxometry.They researched the compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran( cas:17739-45-6 ).Related Products of 17739-45-6. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:17739-45-6) here.
The properties of LnIII-HPDO3A complexes as relaxation enhancers and paraCEST agents are essentially related to the hydroxylpropyl moiety. A series of three HPDO3A derivatives, with small modifications to the hydroxyl arm, were herein studied to understand how heightened control can be gained over the parameters involved in the design of these agents. A full 1H and 17O-NMR relaxometric anal. was conducted and demonstrated that increasing the length of the OH group from the lanthanide center significantly enhanced the water exchange rate of the gadolinium complex, but with a subsequent reduction in kinetic stability. Alternatively, the introduction of an addnl. Me group, which increased the steric bulk around the OH moiety, gave almost exclusively the TSAP isomer (95 %) as identified by 1H-NMR of the europium complex. The gadolinium analog of this complex also exhibited a very fast water exchange rate, but with no detectable loss of kinetic stability. This complex therefore demonstrates a notable improvement over Gd-HPDO3A.
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem