Recommanded Product: (R)-(-)-3-Fluoropyrrolidine Hydrochloride. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, is researched, Molecular C4H9ClFN, CAS is 136725-55-8, about Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA. Author is Campbell, Nancy H.; Smith, Daniel L.; Reszka, Anthony P.; Neidle, Stephen; O’Hagan, David.
Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analog, and with a different binding mode involving reversal of the pyrrolidinium N+-H orientation.
Here is just a brief introduction to this compound(136725-55-8)Recommanded Product: (R)-(-)-3-Fluoropyrrolidine Hydrochloride, more information about the compound((R)-(-)-3-Fluoropyrrolidine Hydrochloride) is in the article, you can click the link below.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem