The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ) is researched.Formula: C10H9NO2.Saleh, Nidal; Voituriez, Arnaud published the article 《Synthesis of 9H-Pyrrolo[1,2-a]indole and 3H-Pyrrolizine Derivatives via a Phosphine-Catalyzed Umpolung Addition/Intramolecular Wittig Reaction》 about this compound( cas:21778-81-4 ) in Journal of Organic Chemistry. Keywords: pyrrolo indole preparation; pyrrolizine preparation; phosphine catalyzed umpolung addition Wittig indole carbaldehyde acetylene dicarboylate. Let’s learn more about this compound (cas:21778-81-4).
The first umpolung addition/intramol. Wittig reaction, catalytic in phosphine, is described. The in situ phosphine oxide reduction was accomplished by the use of silane and a catalytic amount of bis(4-nitrophenyl)phosphate. This catalytic protocol is applicable to the synthesis of a wide range of functionalized 9H-pyrrolo[1,2-a]indoles and pyrrolizines (18 examples, 70-98% yields).
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem