In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Discovery of novel 4-phenyl-2-(pyrrolidinyl)nicotinamide derivatives as potent Nav1.1 activators, published in 2019-03-15, which mentions a compound: 136725-55-8, mainly applied to phenyl pyrrolidinyl nicotinamide derivative preparation sodium channel CNS disease; Dravet syndrome phenyl pyrrolidinyl nicotinamide derivative preparation; BBB penetration; Dravet syndrome; Na(v)1.1 activator; Slow current decay of inactivation; Voltage-gated sodium channels, Formula: C4H9ClFN.
The voltage-gated sodium channel, Nav1.1, is predominantly expressed in parvalbumin-pos. fast spiking interneurons and has been genetically linked to Dravet syndrome. Starting from a high throughput screening hit isoxazole derivative 5, modifications of 5 via combinations of IonWorks and Q-patch assays successfully identified the nicotinamide derivative 4. Its increasing decay time constant (tau) of Nav1.1 currents at 0.03 μM along with significant selectivity against Nav1.2, Nav1.5, and Nav1.6 and acceptable brain exposure in mice was observed Compound 4 is a promising Nav1.1 activator that can be used to analyze pathophysiol. functions of the Nav1.1 channel towards treating various central nervous system diseases.
Compound(136725-55-8)Formula: C4H9ClFN received a lot of attention, and I have introduced some compounds in other articles, similar to this compound((R)-(-)-3-Fluoropyrrolidine Hydrochloride), if you are interested, you can check out my other related articles.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem