Extracurricular laboratory: Synthetic route of 21778-81-4

Here is just a brief introduction to this compound(21778-81-4)Formula: C10H9NO2, more information about the compound(5-Methoxy-1H-indole-2-carbaldehyde) is in the article, you can click the link below.

Zhang, Lei; Zhao, Fei; Zheng, Mingyue; Zhai, Yun; Wang, Jiang; Liu, Hong published an article about the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4,SMILESS:O=CC(N1)=CC2=C1C=CC(OC)=C2 ).Formula: C10H9NO2. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:21778-81-4) through the article.

In combination with the Ugi four-component reaction, two important indole-fused heterocycles were prepared in two steps from readily accessible starting materials. From the same set of Ugi adducts 5, 5,6-dihydroindolo[1,2-a]quinoxalines were rapidly generated in excellent yields by a copper-catalyzed N-H arylation pathway, whereas 6,7-dihydroindolo[2,3-c]quinolones were obtained by palladium-catalyzed C-H arylations in good yields without the protection of the indole N1 moiety. Microwave heating was used to accelerate these intramol. C-N and C-C bond-forming reactions performed under controlled reaction conditions.

Here is just a brief introduction to this compound(21778-81-4)Formula: C10H9NO2, more information about the compound(5-Methoxy-1H-indole-2-carbaldehyde) is in the article, you can click the link below.

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem