The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 5-Methoxy-1H-indole-2-carbaldehyde(SMILESS: O=CC(N1)=CC2=C1C=CC(OC)=C2,cas:21778-81-4) is researched.Product Details of 136725-55-8. The article 《Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists》 in relation to this compound, is published in Bioorganic & Medicinal Chemistry Letters. Let’s take a look at the latest research on this compound (cas:21778-81-4).
5-Oxo-ETE is the most potent eosinophil chemoattractant among lipid mediators. We have developed two 5-oxo-ETE receptor antagonists. In the course of the work, we have developed a procedure to selectively introduce a cis and trans double bond in an alkyl side chain. Reacting indolecarboxaldehydes with alkyl ylides using the Li base affords the trans olefins, whereas using the K base yields the cis olefins.
From this literature《Base-dependent formation of cis and trans olefins and their application in the synthesis of 5-oxo-ETE receptor antagonists》,we know some information about this compound(21778-81-4)Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde, but this is not all information, there are many literatures related to this compound(21778-81-4).
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem