A new synthetic route of 21778-81-4

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Fetizon, Marcel; Gomez-Parra, Federico; Louis, Jean M. published an article about the compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4,SMILESS:O=CC(N1)=CC2=C1C=CC(OC)=C2 ).Application of 21778-81-4. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:21778-81-4) through the article.

Oxidation of primary and secondary alcs. in heterocyclic series by AgCO3 absorbed on Celite gave aldehydes or ketones with excellent yields. Also oxidized were the alcs. containing the furan, pyrrole, thiophene, pyridine, or indole nucleus. The oxidation of codeine and of dihydrocodeine also was studied. Although the AgCO3 did not react with dihydrocodeine, the oxidation occurred using Ag2CO5-Celite. The yield for codeinone is better than 91%. Tetrahydrofurfuryl alc. and 2-hydroxymethyltetrahydropyran were slowly degraded to γ-butyrolactone and δ-valerolactone, resp.

From this literature《Oxidation by silver carbonate on celite. XV. Heterocyclic alcohols》,we know some information about this compound(21778-81-4)Application of 21778-81-4, but this is not all information, there are many literatures related to this compound(21778-81-4).

Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem