Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17739-45-6, is researched, SMILESS is BrCCOC1CCCCO1, Molecular C7H13BrO2Journal, Article, Molecules called Combining chalcones with donepezil to inhibit both cholinesterases and Aβ fibril assembly, Author is Chandrika, Nishad Thamban; Fosso, Marina Y.; Tsodikov, Oleg V.; Levine, Harry III; Garneau-Tsodikova, Sylvie, the main research direction is chalcone donepezil cholinesterase amyloid beta fibril Alzheimer disease; 3H-PIB binding; Alzheimer’s disease; Aβ assembly; Aβ dissociation; acetylcholinesterase; butyrylcholinesterase.Formula: C7H13BrO2.
The fact that the number of people with Alzheimer’s disease is increasing, combined with the limited availability of drugs for its treatment, emphasize the need for the development of novel effective therapeutics for treating this brain disorder. Herein, we focus on generating 12 chalcone-donepezil hybrids, with the goal of simultaneously targeting amyloid-β (Aβ) peptides as well as cholinesterases (i.e., acetylcholinesterase (AChE) and butyrylcholinesterase (BChE)). We present the design, synthesis, and biochem. evaluation of these two series of novel 1,3-chalcone-donepezil (15a-15f) or 1,4-chalcone-donepezil (16a-16f) hybrids. We evaluate the relationship between their structures and their ability to inhibit AChE/BChE activity as well as their ability to bind Aβ peptides. We show that several of these novel chalcone-donepezil hybrids can successfully inhibit AChE/BChE as well as the assembly of N-biotinylated Aβ(1-42) oligomers. We also demonstrate that the Aβ binding site of these hybrids differs from that of Pittsburgh Compound B (PIB).
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