The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: 5-Methoxy-1H-indole-2-carbaldehyde( cas:21778-81-4 ) is researched.Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde.Kuehn-Caubere, Catherine; Rodriguez, Ivan; Pfeiffer, Bruno; Renard, Pierre; Caubere, Paul published the article 《Efficient selective synthesis of 2-substituted indoles from complex-base-promoted arynic cyclizations》 about this compound( cas:21778-81-4 ) in Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry. Keywords: indole preparation arynic cyclization; imine methyl ketone preparation cyclization; thiopyranoindole tetrahydro preparation ring cleavage; mercaptopropylindole preparation. Let’s learn more about this compound (cas:21778-81-4).
Indoles I [R = 5-MeO, 5-Me, 5-F, 7-Me, 5-MeO, 5-Cl, H; R1 = H, MeO; R2 = n-Pr, i-Pr, allyl, (CH2)2NEt2, (CH2)2NMe2, (CH2)2OEt, MeO] were efficiently obtained by selective arynic cyclization of halogenated aryl imines, e.g. 3,4-Cl(MeO)C6H3N:CMeCH2CH2CH2Me, in the presence of the complex-base NaNH2-Me3CONa. (Mercaptopropyl)indoles II (R = 5-OH, 7-OH; R3 = H, Me, CH2Ph, CH2CO2Et) were prepared by PhCH2SH-AlCl3 promoted opening of tetrahydrothiopyranoindoles which were also obtained from arynic cyclization of imines.
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Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem