Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 17739-45-6, is researched, SMILESS is BrCCOC1CCCCO1, Molecular C7H13BrO2Journal, Article, Research Support, Non-U.S. Gov’t, Molecular Pharmaceutics called Novel 18F-Labeled Isonicotinamide-Based Radioligands for Positron Emission Tomography Imaging of Glycogen Synthase Kinase-3β, Author is Zhong, Yuhua; Yang, Shaoxi; Cui, Jianyu; Wang, Jie; Li, Lin; Chen, Yilin; Chen, Junjie; Feng, Pengju; Huang, Shun; Li, Hongsheng; Han, Yanjian; Tang, Ganghua; Hu, Kongzhen, the main research direction is fluorine 18 isonicotinamide radioligand preparation PET imaging GSK3 brain; 18F-labeled; GSK-3β; PET; brain; isonicotinamide.HPLC of Formula: 17739-45-6.
Glycogen synthase kinase-3β (GSK-3β), a cytoplasmic serine/threonine protein kinase, is involved in several human pathologies including Alzheimer’s disease, bipolar disorder, diabetes, and cancer. Positron emission tomog. (PET) imaging of GSK-3β could aid in investigating GSK-3β levels under normal and pathol. conditions. In this study, we designed and synthesized fluorinated PET radioligands starting with recently identified isonicotinamide derivatives that showed potent affinity to GSK-3β. After extensive in vitro inhibitory activity assays and analyzing U87 cell uptake, we identified [18F]10a-d as potential tracers with good specificity and high affinity. They were then subjected to further in vivo evaluation in rodent brain comprising PET imaging and metabolism studies. The radioligands [18F]10b-d penetrated the blood-brain barrier and accumulated in GSK-3β-rich regions, including amygdala, cerebellum, and hippocampus. Also, it could be specifically blocked using the corresponding standard compounds With these results, this work sets the basis for further development of novel 18F-labeled GSK-3β PET probes.
This literature about this compound(17739-45-6)HPLC of Formula: 17739-45-6has given us a lot of inspiration, and I hope that the research on this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran) can be further advanced. Maybe we can get more compounds in a similar way.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem