The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: (R)-(-)-3-Fluoropyrrolidine Hydrochloride( cas:136725-55-8 ) is researched.Quality Control of (R)-(-)-3-Fluoropyrrolidine Hydrochloride.Campbell, Nancy H.; Smith, Daniel L.; Reszka, Anthony P.; Neidle, Stephen; O’Hagan, David published the article 《Fluorine in medicinal chemistry: β-fluorination of peripheral pyrrolidines attached to acridine ligands affects their interactions with G-quadruplex DNA》 about this compound( cas:136725-55-8 ) in Organic & Biomolecular Chemistry. Keywords: fluorine medicinal chem fluorination pyrrolidine acridine G quadruplex DNA. Let’s learn more about this compound (cas:136725-55-8).
Comparative X-ray structure studies reveal that C-F bond incorporation into the peripheral pyrrolidine moieties of the G-quadruplex DNA binding ligand BSU6039 leads to a distinct pyrrolidine ring conformation, relative to the non-fluorinated analog, and with a different binding mode involving reversal of the pyrrolidinium N+-H orientation.
There is still a lot of research devoted to this compound(SMILES：Cl.F[C@@H]1CCNC1)Quality Control of (R)-(-)-3-Fluoropyrrolidine Hydrochloride, and with the development of science, more effects of this compound(136725-55-8) can be discovered.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem