COA of Formula: C7H13BrO2. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran, is researched, Molecular C7H13BrO2, CAS is 17739-45-6, about Enantioselective Synthesis of Ozanimod, the Active Pharmaceutical Ingredient of a New Drug for Multiple Sclerosis.
We report here a short enantioselective synthesis of Ozanimod (I), a potent modulator of the enzyme Sphingosine-1-phosphate receptor (S1PR), recently approved by FDA and EMA for the treatment of relapsing-remitting multiple sclerosis. Amongst different synthetic approaches explored, we achieved the best result introducing the stereogenic center in the last step through imine asym. transfer hydrogenation (ATH) using Wills’ catalysts. Besides the reduced numbers of enantiomeric purity controls required, this process culminates in an exceptionally high enantioselective reductive amination obtained with com. available tethered Ru catalysts. Starting from com. available 4-cyano-indanone, enantiomerically pure Ozanimod was obtained in 5 steps in 62% overall yield and 99% ee.
If you want to learn more about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)COA of Formula: C7H13BrO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17739-45-6).
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem