The three-dimensional configuration of the ester heterocycle is basically the same as that of the carbocycle. Compound: 2-(2-Bromoethoxy)tetrahydro-2H-pyran(SMILESS: BrCCOC1CCCCO1,cas:17739-45-6) is researched.HPLC of Formula: 60827-45-4. The article 《Multifunctional nanoassemblies target bacterial lipopolysaccharides for enhanced antimicrobial DNA delivery》 in relation to this compound, is published in Colloids and Surfaces, B: Biointerfaces. Let’s take a look at the latest research on this compound (cas:17739-45-6).
The development of new therapeutic strategies against multidrug resistant Gram-neg. bacteria is a major challenge for pharmaceutical research. Here, we explore the multifunctional therapeutic potential of nanostructured self-assemblies from a cationic bolaamphiphile, which target bacterial lipopolysaccharides (LPSs) and associates with an anti-bacterial nucleic acid to form nanoplexes with therapeutic efficacy against Gram-neg. bacteria. To understand the mechanistic details of these multifunctional antimicrobial-anti-inflammatory properties, we performed a fundamental study, comparing the interaction of these nanostructured therapeutics with synthetic biomimetic bacterial membranes and live bacterial cells. Combining a wide range of exptl. techniques (Confocal Microscopy, Fluorescence Correlation Spectroscopy, Microfluidics, NMR, LPS binding assays), we demonstrate that the LPS targeting capacity of the bolaamphiphile self-assemblies, comparable to that exerted by Polymixin B, is a key feature of these nanoplexes and one that permits entry of therapeutic nucleic acids in Gram-neg. bacteria. These findings enable a new approach to the design of efficient multifunctional therapeutics with combined antimicrobial and anti-inflammatory effects and have therefore the potential to broadly impact fundamental and applied research on self-assembled nano-sized antibacterials for antibiotic resistant infections.
If you want to learn more about this compound(2-(2-Bromoethoxy)tetrahydro-2H-pyran)COA of Formula: C7H13BrO2, you may wish to communicate with the author of the article,or consult the relevant literature related to this compound(17739-45-6).
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem