In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Development and Synthesis of DNA-Encoded Benzimidazole Library, published in 2018-05-14, which mentions a compound: 21778-81-4, mainly applied to preparation DNA conjugated benzimidazole library NK3 receptor antagonist; DNA tagged fluoronitrobenzamide amine aldehyde; DNA-encoded library technology; benzimidazole, Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde.
Encoded library technol. (ELT) is an effective approach to the discovery of novel small-mol. ligands for biol. targets. A key factor for the success of the technol. is the chem. diversity of the libraries. Here we report the development of DNA-conjugated benzimidazoles. Using 4-fluoro-3-nitrobenzoic acid as a key synthon, we synthesized a 320 million-member DNA-encoded benzimidazole library using Fmoc-protected amino acids, amines and aldehydes as diversity elements. Affinity selection of the library led to the discovery of a novel, potent and specific antagonist of the NK3 receptor.
Here is a brief introduction to this compound(21778-81-4)Quality Control of 5-Methoxy-1H-indole-2-carbaldehyde, if you want to know about other compounds related to this compound(21778-81-4), you can read my other articles.
Reference:
Pyridazine – Wikipedia,
Pyridazine | C4H4N2 – PubChem